'Peter Attia, MD, is one of the leading thought leaders in the field of enhancing lifespan through dietary changes, intermittent fasting (IF) and exercise. In this show, we discuss a range of exciting topics with a focus on enhancing autophagy and inhibiting mTOR through nutrition, fasting and pharmacology. ➢ Subscribe to Peter\'s Channel: https://www.youtube.com/channel/UCXGAY7QiNeBY7VVNZtqmUxA ➢Check out Peter\'s Amazing Podcast https://podcasts.apple.com/us/podcast/the-peter-attia-drive/id1400828889 ➢Links to full show notes and studies: http://bit.ly/2QWLAAY -----------------------------------------Lets Connect-------------------------------------- ➢Audio Podcast: https://podcasts.apple.com/us/podcast/267-fasting-autophagy-mtor-inhibition-w-peter-attia-md/id910048041?i=1000442525143 ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- VIDEO GEAR & TOOLS----------------------------------------------- Gravity Blanket (use code HIH10 to save): http://shrsl.com/1o7wi A Metabolism Book Should Have:https://amzn.to/2jUiAh5 Best iPhone Stabilizer: https://amzn.to/2IuCFFw Vlog Cam Canon M50: https://amzn.to/2jRBTEd Sony Vlog Cam: https://amzn.to/2DhRV4j Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -------------------------------------- Key Timestamps---------------------------------- Links to full show notes and studies: http://bit.ly/2QWLAAY 0:00 intro 04:14: Endurance athletics and lactate testing 06:10: Doping in endurance sports: why cycling is not really clean 08:22 Training adaptations and MCT transporters 10:34 The cori cycle in the liver turns lactate back into glucose. The brain can use lactate directly as a fuel. 11:43 Longevity has no clinical trial. 13:42 Two interventions that offer longevity in animal models: fasting and Rapamycin. Both downregulate mTOR and both support autophagy. 15:35 Rapamycin is used for immune suppression in patients who have had organ transplants. 25:02 Dr. Attia does not use telomere’s as a marker of ageing since so many other things can influence it. 26:48 We need a blood test that measures some sort of signature autophagy. 28:46 Fasting is the single most potent tool in our toolbox of nutrition. 32:53 There are 50 different fasting regimens called intermittent fasting and we have no way to rank them or customize them to people’s goals. 34:20 Every gram of glycogen moves with 3 to 4 grams of water. The water goes into the plasma first and then out again as your body tries to conserve sodium. 41:58 Methionine levels drop quickly in fasting. Leucine levels remain about the same even 7 days in. 43:54 Research found that T4 and T3 decreased in the first 3 days of a fast, but leveled out after that. 45:35 In a fasted state, your body upregulates the enzyme that converts T4 into reverse T3. 50:33 At the end of a fast, Dr. Attia has very low testosterone, but experiences little to no symptoms or reduction in strength. 55:53 The literature on NAD is confusing. 01:00:24 Fasting is the single most important tool for treating metabolic disease and should be a part of any protocol. 01:04:09 People who do not do well on a ketogenic diet may have issues with the enzymes that regulate ketogenesis. 01:07:14 Metformin has a possible use as a longevity agent. 01:11:59 Berberine and Metformin go after the same pathway and probably should not be taken together. 01:21:05 Dr. Attia’s morning routine: He gets up early, listens to a lesson and meditates using apps 10% Happier or Waking Up.'
Tags: intermittent fasting , peter attia , autophagy , time restricted eating , time restricted feeding , Centenarians , mTOR , rapamycin , mTOR inhibition
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