'Immune Cells Use Sugar to Drive Inflammation w/ Alena Guggenheim, ND'

'Immune Cells Use Sugar to Drive Inflammation w/ Alena Guggenheim, ND'
52:44 May 29, 2023
'Science says eating just one meal per day can improve your health.  Learn more at https://highintensityhealth.com/OMAD  -----  This could be one of the most important discussions we\'ve had up to now.   We discuss a rather complex topic: immunometabolism. This emerging field is the intersection between metabolism and immunity.   Understanding it is key to unraveling how metabolic therapies (ketogenic diet) and fasting affect the whole body; including the immune system.   ➢This episode is brought to you by MYOXCIENCE Nutrition https://www.amazon.com/myoxcience  New Keto + MCT MicroDose: https://amzn.to/2MSJVuf  ➢Connect with Alena: https://www.ohsu.edu/providers/alena-guggenheim/44D98531F4B4E53A771C5A8204074F7E  Links to Top Resources Discussed:   ➢ Perfect Keto, the makers of high-quality exogenous ketones and MCT oil products.   *Save over 20% OFF: https://www.perfectketo.com/HIH  **We love their new Salted Carmel product  Joovv Light: https://lddy.no/3pck Save w/ code: HIH  Oura Ring: https://ouraring.com/ Save $50 w/ code HIH  -----------------------------------------Lets Connect--------------------------------------  ➢ iTunes Podcast: https://highintensityhealth.com/itunes  ➢ Instagram https://www.instagram.com/metabolic_mike  ➢ Facebook https://www.facebook.com/MikeMutzelMS   -------------------------------------- VIDEO GEAR-------------------------------------------------  Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ  Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5  Interview Cam C100 ii: https://amzn.to/2EC5NE8  Best Lens Ever: https://amzn.to/2IJ9WZC  Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo  Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h  Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm  -------------------------------------- Key Timestamps----------------------------------   04:46 Your immune system can accidently attack the body or it may miss something that has gone wrong, like cancer growth.  05:12 The immune system, via inflammation, plays a role in all sorts of diseases and chronic diseases, like diabetes and heart disease.  05:44 Different parts of your immune system have different preferred food sources.  07:07 Our immune system has peacekeepers, T-regulatory cells and B-regulatory cells. The depletion of Treg and Breg cells is implicated in every autoimmune disease.  07:50 Everything the immune system does is metabolically costly and takes money, in the form of ATP.  09:30 The peacekeepers prefer fatty acid metabolism.  11:13 High CRP is not your body responding to any specific thing.  14:00 Metformin is being researched of its use in treating Lupus.  15:39 Mitochondria are responsible for metabolism, making energy in your cells.  16:57 Mitochondrial dysfunction is present in inflammatory disorders.  17:35 Our mitochondria are symbionts that probably came from bacteria and are vulnerable to some of the same things that damage bacteria, like antibiotics and pesticides.  19:16 You can only poison your mitochondria so much.  20:20 The cheapest and most effective mitochondrial nutrient is N-acetylcysteine.  21:46 Berberine is similar metabolically to Metformin, but there is not the body of evidence that there is with diabetic research.  24:58 If you don’t have enough mTOR, you will not get new cell building and you go into breakdown phase.  27:53 Beta hydroxybutyrate feeds your peacekeeper T-regs.  29:20 Macrophages are sentinels, to sense the general environment. They sense microbes, metabolism, nutrients, temperature and can probably sense light. 31:33 The macrophages inside visceral fat tend to be m2 and cause metabolic disturbance, increasing levels of inflammation.  36:18 T-reg signaling is dependent upon vitamin D.  38:04 Labs for immune, metabolic or hormone health are snapshots, especially with diurnal hormones.  42:01 The first thing you can do to improve your metabolic health is to follow the Okinawan Hara Hachi Bu. Eat until you are 80% full.  43:39 You cannot listen to your satiety signals if you eat quickly.  46:56 Dr. Guggenheim’s morning routine centers around her kids. First thing, she drinks something warm.  49:45 Dr. Guggenheim’s desert island nutrient is curcumin.  50:42 Dr. Guggenheim’s elevator pitch is a recommendation for a policy change to discontinue food subsidies.' 

Tags: keto , ketodiet , autoimmunity , t regulatory cell , immunometabolism , inflammaging , Alena Guggenheim

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